Accelerating the path from Hit Identification to IND Submission
Syner-G’s Discovery Sciences team provides comprehensive medicinal chemistry services to support the journey from early discovery to clinical candidate nomination. With over 50 years of deep industry expertise, we help biotech innovators overcome common barriers in molecule optimization and lead development. Our focus is on enabling data-driven, scientific decisions that accelerate the advancement of compounds into successful clinical candidates. We help our clients ensure a seamless transition between discovery and development phases, enabling quicker IND filings and driving clinical success.
Who We Serve
We partner with early-stage and emerging biotech companies ready to advance beyond tool compounds or hit series. Whether you’ve just achieved proof of concept or are managing multiple active programs, our Discovery Sciences team delivers flexible, science-led support
What We Do
We partner with our clients throughout the discovery process, from hit identification to IND-enabling studies, providing expert guidance, science-led solutions, and a reliable network of partners. Our goal is to fast-track discovery, improve compound quality, mitigate development risks, and prepare candidates for clinical success. With our holistic approach and deep industry experience, we empower clients to accelerate their discovery programs, optimize safety profiles, and increase the likelihood of achieving successful clinical outcomes
Small Molecule Design and Synthesis
Our expert team guides clients in lead development and the design and synthesis of small molecules specifically targeted to be effective against chosen biological targets, optimizing for potency and physiological profile including ADME, toxicity, and PK/PD.
Drug Development Readiness
We help clients in advancing from hit discovery to lead candidate nomination and IND submission by providing necessary frameworks and critical resources for scale-up, process optimization, formulation development, analytical development, and stability testing—ensuring your compounds are prepared for clinical phases.
Toxicology Assessment & Guidance
We provide toxicity services to help predict how alterations to a molecule's chemical structure may influence its potential toxicity. Our offerings include the preparation and execution of GLP toxicity studies, which support IND submission and evaluate key safety concerns such as mutagenicity. Our focus is to enable informed decision-making throughout the development process and help streamline the pathway to regulatory approval.
Key Services
High Quality Structure Activity Relationship (SAR) Development and Design
Chemical Structure and Biological and Pharmacokinetic Database Management
Design and Development of Optimized Compound Synthesis
CRO & CDMO Partner Evaluation, Selection, and Oversight
Why Syner-G
Medicinal Chemistry Expertise
With over 50 years of experience, our expert scientists bring deep medicinal chemistry expertise in high-quality compound selection and optimization to drive your discovery programs forward.
Integrated, End-to-End Support
As a single, science-led partner, we support our clients across discovery, development, and preclinical stages—providing reliable supply chains, accelerating IND filings, and facilitating clinical success.
Accelerated Timelines
Our custom solutions help speed up development timelines by months or even years while reducing risks from hit discovery to IND, enhancing investor confidence and ensuring clinical readiness.
Trusted Network
Our extensive network of consultants, CROs, and CDMOs minimizes execution risks and ensures quality at every phase of your program.
Download our biobook to learn more about the team and meet our Medicinal Chemistry experts.
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